Title :
Methods and algorithms for the design of proteins
fDate :
2/28/1994 12:00:00 AM
Abstract :
Protein design is a burgeoning new field of structural molecular biology, which entails selecting sequences of amino acids to fold into a desired pre-determined structure. The authors present a quantitative methodology for the de novo design of proteins as well as supporting algorithms, including a massively parallel simulated annealing optimization method. With these algorithms it is possible to choose sequences which should adopt an arbitrary plausible structure
Keywords :
biology computing; macromolecular configurations; molecular biophysics; parallel algorithms; proteins; simulated annealing; arbitrary plausible structure; de novo design; design of proteins; massively parallel simulated annealing optimization; quantitative methodology; sequences of amino acids; structural molecular biology;
Conference_Titel :
Molecular Bioinformatics, IEE Colloquium on
