Title :
Resonant slot antennas as transducers of DNA hybridization: a computational feasibility study
Author :
Wichaidit, C. ; Peck, J.R. ; Zhang Lin ; Hamers, R.J. ; Hagness, S.C. ; van der Weide, D.W.
Author_Institution :
Dept. of Electr. & Comput. Eng., Wisconsin Univ., Madison, WI, USA
Abstract :
We propose and simulate a resonant slot antenna for sensing DNA hybridization. Using simple geometric arguments for water displacement from a DNA-functionalized surface, we predict the changes in dielectric constants caused by hybridization. We conclude that these changes are significant enough to be detected in measurements of the resonant frequency and the surface currents of a slot antenna. These results motivate experimental work using these antennas as alternatives to current fluorescence probes.
Keywords :
DNA; biosensors; permittivity; probes; slot antennas; surface chemistry; DNA hybridization; DNA-functionalized surface; computational feasibility study; dielectric constants; geometric arguments; resonant frequency; resonant slot antennas; surface currents; water displacement; Antenna measurements; Current measurement; DNA; Dielectric constant; Dielectric measurements; Frequency measurement; Resonance; Resonant frequency; Slot antennas; Transducers;
Conference_Titel :
Microwave Symposium Digest, 2001 IEEE MTT-S International
Print_ISBN :
0-7803-6538-0
DOI :
10.1109/MWSYM.2001.966863
