Inhomogeneous anisotropic bidomain modeling of cardiac tissue

In this paper we describe a new finite difference bidomain formulation for a cardiac tissue with intramural fiber rotation. The cardiac tissue consists of discrete layers of fibers arranged at different angular orientations within the tissue. The angular rotation of the fiber creates anisotropy in the tissue´s intracellular and interstitial conductivities which vary from one layer to another, i.e., inhomogeneous. The new inhomogeneous anisotropic bidomain formulation will allow a more realistic modeling of the cardiac tissue. Mathematical formulation of the new method and its validation are presented.