The initial effects of scopolamine on the electroencephalogram in healthy human subjects

Author

Johannesson, G.H. ; Gudmundsdottir, I.R. ; Helgason, J. ; Ofeigsson, B.G. ; Hrafnkelsdottir, K. ; Olafsson, D.R. ; Kristinsson, J.L. ; Stefansson, S. ; Gizurarson, S. ; Johnsen, K.

Author_Institution

Lyfjathroun Biopharmaceuticals, Reykjavik, Iceland

Volume

3

fYear

2003

Firstpage

2523

Abstract

We find that the initial effects of scopolamine on the alpha frequency band (7-13 Hz) part of an electroencephalogram (EEC) in healthy human subjects can be characterized using a first order decay model for the relative power contained in the band. We have studied the effects on EEG immediately after injection of scopolamine (i.v.) using an auditory evoked potential series, where the subjects were instructed to count odd signals in the series. This amplifies the activity in the alpha-band and possibly the effect of scopolamine. Eight young healthy human subjects participated in the study and all showed an initial decrease in the relative power of the alpha-band. In contrast the relative power in the alpha-band increased in all subjects when placebo was administered.

Keywords

auditory evoked potentials; diseases; electroencephalography; 7 to 13 Hz; Alzheimer disease; EEC; alpha frequency band; alpha-band; auditory evoked potential series; dementia; electroencephalogram; first order decay model; healthy human subjects; scopolamine initial effects; Alzheimer´s disease; Brain modeling; Dementia; Drugs; Electroencephalography; Frequency; Hospitals; Humans; Nervous system; Senior citizens;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE

ISSN

1094-687X

Print_ISBN

0-7803-7789-3

Type

conf

DOI

10.1109/IEMBS.2003.1280429

Filename

1280429