Title :
Network thermodynamic model of drug transfer through skin for transdermal drug delivery in vitro
Author :
Hong, Wang ; Jiali, Bao ; Jiguang, Ge ; Ping, Wu
Author_Institution :
Coll. of Medicine, Zhejiang Univ., Hangzhou, China
Abstract :
The purpose of this study is to illustrate the non-equilibrium properties of drug permeation through stratum corneum (SC) to provide theory and method for transdermal drug delivery (TDD). The side-by-side permeation cell in vitro was supposed to be isolated system, thus conditions for equilibrium state were decided and a network thermodynamic model was established. We completed non-equilibrium experiment with which Tinidazole was pattern drug. Results show that the non-equilibrium properties include: (1) long term to reach equilibrium state; (2) delay-start of the permeation; and (3) uncertainty of initial drug permeable flux. Results also demonstrate the properties of leakage which include degression of drug permeable flux and changeability of permeation time constant. Hence, the permeation cell is believed to be a non-linear and time variable system.
Keywords :
biomembranes; drug delivery systems; permeability; skin; thermodynamic properties; Tinidazole; drug permeable flux; drug permeation; drug transfer; leakage properties; network thermodynamic model; nonequilibrium properties; side-by-side permeation cell; skin; stratum corneum; transdermal drug delivery; Chemicals; Delay; Drug delivery; Entropy; In vitro; Magnetic flux; Skin; Temperature; Thermodynamics; Uncertainty;
Conference_Titel :
Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE
Print_ISBN :
0-7803-7789-3
DOI :
10.1109/IEMBS.2003.1280541