RBF method for optimal control of drug administration in the anemia of hemodialysis patients

Author

Mirinejad, Hossein ; Inanc, Tamer

Author_Institution

Dept. of Electr. & Comput. Eng., Univ. of Louisville, Louisville, KY, USA

fYear

2015

Firstpage

1

Lastpage

2

Abstract

Anemia is a common complication of the end-stage renal disease (ESRD) that is efficiently treated by the administration of recombinant human erythropoietin (EPO). While a low-dose EPO cannot treat the anemia effectively, an excessive EPO dose may increase the risk of serious heart problems and blood clots. Therefore, the optimal control of EPO administration is of great importance in the treatment of anemia. In this work, a radial basis function (RBF) method is introduced and successfully applied to the EPO drug dosing problem. The simulation results show the effectiveness of the method for the optimal control of EPO administration in the anemia of hemodialysis patients.

Keywords

diseases; drug delivery systems; drugs; medical control systems; optimal control; radial basis function networks; EPO drug dosing problem; RBF method; anemia treatment; blood clots; drug administration; end-stage renal disease; heart problems; hemodialysis patients; optimal control; radial basis function method; recombinant human erythropoietin; Approximation methods; Diseases; Drugs; Kidney; Optimal control; Optimization; Red blood cells; RBF method; anemia; drug dosing; erythropoietin (EPO); hemoglobin; optimal control;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Engineering Conference (NEBEC), 2015 41st Annual Northeast

Print_ISBN

978-1-4799-8358-2

Type

conf

DOI

10.1109/NEBEC.2015.7117180

Filename

7117180