Title :
Beta-adrenergic modulation of heart rate: Contribution of the slow delayed rectifier K+ current (IKs)
Author :
Wilders, Ronald ; Hoekstra, Maaike ; Van Ginneken, Antoni C G ; Verkerk, A.O.
Author_Institution :
Acad. Med. Center, Univ. of Amsterdam, Amsterdam, Netherlands
Abstract :
To assess the role of the slow delayed rectifier potassium current (IKs) in the β-adrenergic modulation of heart rate, we experimentally determined the effect of β adrenergic stimulation on IKs and used the thus obtained data in computer simulations of SA nodal pacemaker activity, employing the mathematical model of a primary rabbit SA node pacemaker cell by Kurata and coworkers. Incorporation of our experimental findings into the SA nodal cell model resulted in a 12 ms decrease in cycle length. This decrease in cycle length is similar to the 13 ms decrease observed upon incorporation of our experimental data on the effect of β-adrenergic stimulation on the hyperpolarization-activated funny current´ (If), also known as ´pacemaker current´. We conclude that IKs is an important contributor to the β-adrenergic modulation of heart rate.
Keywords :
current density; data analysis; electrocardiography; mathematical analysis; medical diagnostic computing; pacemakers; potassium; β-adrenergic modulation; SA nodal cell model; SA nodal pacemaker activity; beta-adrenergic modulation; current density; data analysis; heart rate; hyperpolarization-activated funny current; mathematical model; slow delayed rectifier potassium current; Computational modeling; Current density; Electric potential; Heart rate; Modulation; Pacemakers; Rabbits;
Conference_Titel :
Computing in Cardiology, 2010
Print_ISBN :
978-1-4244-7318-2