• DocumentCode
    3596490
  • Title

    Matrix-Based Analytical Methods for Recasting Jacobian Models to Power-Law Models

  • Author

    Idowu, Michael A. ; Bown, James L.

  • Author_Institution
    SIMBIOS Centre, Univ. of Abertay, Dundee, UK
  • fYear
    2013
  • Firstpage
    250
  • Lastpage
    258
  • Abstract
    New methods for inferring data-consistent, self-reconfigurable power-law models from time series data are required and developed. These novel methods may be categorised into two broad groups, namely: straightforward (or direct) inference methods based on power-law models; and a jacobian based indirect inference method. The direct method involves applying direct means to infer a power-law model from time series data. The indirect method, however, uses a new system identification method to first infer a jacobian model as instant and temporal solution to the inverse problem before recasting the inferred jacobian model to corresponding power-law model using our newly developed recast technique. The recast method, in addition to normal behaviour, also provides a novel analytical technique for integrating power-law and jacobian models together. The modelling approach we have developed extends previous work on matrix-based network inference to model interoperability and multiple model transformation in terms of finding two distinct models (solutions) to an inverse problem.
  • Keywords
    Jacobian matrices; inverse problems; parameter estimation; time series; Jacobian based indirect inference method; inferred Jacobian model; inverse problem; matrix-based analytical methods; matrix-based network inference; multiple model transformation; recast technique; self-reconfigurable power-law models; straightforward inference methods; system identification method; time series data; Analytical models; Biological system modeling; Data models; Jacobian matrices; Kinetic theory; Mathematical model; Time series analysis; mathematical modelling; simulation; reverse engineering; optimisation algorithms; network inference; inverse problems; analytical methods; matrix algebra and calculus; time series analysis; system identification; parameter estimation methods;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Modelling and Simulation (EUROSIM), 2013 8th EUROSIM Congress on
  • Type

    conf

  • DOI
    10.1109/EUROSIM.2013.53
  • Filename
    7004952