Title :
Shear horizontal surface acoustic wave based immunosensing system
Author :
Campitelli, A. ; Wlodarski, W. ; Hoummady, M. ; Sawyer, W.
Author_Institution :
R. Melbourne Inst. of Technol., Vic., Australia
Abstract :
Reports on the design of novel liquid media immunosensors based on shear horizontally polarised surface acoustic wave (SH-SAW) devices for the continuous and direct detection of biological interactions. A portable SH-SAW sensor array system has been developed where SH-SAW devices are fabricated on lithium tantalate piezoelectric substrates. The interaction between bovine immunoglobulin G (IgG) and Protein A was investigated to establish the feasibility of the proposed sensing system. Analysis of the kinetic phases of the interaction are evaluated in real time and preliminary results clearly show that a fast, highly sensitive and reproducible response is obtainable for various IgG concentrations in the range of 1E-7 to 1E-l mg/ml
Keywords :
biomedical equipment; biomedical ultrasonics; biosensors; molecular biophysics; piezoelectric transducers; proteins; surface acoustic wave transducers; ultrasonic transducer arrays; 104 MHz; IgG concentrations; LiTaO3; LiTaO3 piezoelectric substrates; Protein A; biological interactions; bovine immunoglobulin G; continuous detection; direct detection; fast highly sensitive reproducible response; kinetic phases; liquid media immunosensors; portable SH-SAW sensor array system; real time; shear horizontal surface acoustic wave based immunosensing system; shear horizontally polarised surface acoustic wave devices; Acoustic signal detection; Acoustic waves; Biological interactions; Biosensors; Immune system; Piezoelectric polarization; Sensor arrays; Sensor systems; Surface acoustic wave devices; Surface acoustic waves;
Conference_Titel :
Solid State Sensors and Actuators, 1997. TRANSDUCERS '97 Chicago., 1997 International Conference on
Print_ISBN :
0-7803-3829-4
DOI :
10.1109/SENSOR.1997.613614
