Model-augmented investigations on field-stimulated cardiomyocytes

Author

Platzer, D. ; Dapra, D. ; G?¼nter, C. ; Windisch, H.

Author_Institution

Inst. fur Med. Phys. und Biophys., Graz Univ., Austria

Volume

1

fYear

1999

fDate

6/21/1905 12:00:00 AM

Abstract

An experimental and theoretical approach was used to reveal and explain particular complex behavior of cardiac cells under electric field stimuli. The use of straightforward modeling forms a strong alliance with the optical recording technique to adequately explain the underlying mechanisms. Optical recordings reveal behavior that can not be explained by membrane kinetic descriptions established under physiological conditions and lead to an augmented ionic current model for the cardiac ventricular cells under investigation

Keywords

bioelectric phenomena; biological effects of fields; biomembrane transport; cardiology; cellular effects of radiation; electric field effects; muscle; physiological models; augmented ionic current model; cardiac ventricular cells; electric field stimuli; field-stimulated cardiomyocytes; membrane kinetic descriptions; model-augmented investigations; optical recording technique; physiological conditions; Biomedical optical imaging; Biomembranes; Cardiology; Electric shock; Fluorescence; Kinetic theory; Optical pulses; Optical recording; Optical sensors; Pulse measurements;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.802182

Filename

802182