Title :
Mechanisms of elastin calcification and its prevention with aluminum chloride pretreatment
Author :
Vyavahare, Narendra ; Ogle, Matthew ; Schoen, Frederick J. ; Levy, Robert J.
Author_Institution :
Dept. of Pediatrics, Children´´s Hosp. of Philadelphia, PA, USA
fDate :
10/1/1999 12:00:00 AM
Abstract :
Elastin calcification occurs in bioprosthetic heart valve implants. The authors have developed a rat subdermal model to study purified elastin calcification. Purified elastin implants undergo severe calcification within 21 day period and it is found to be poorly crystallin hydroxyapatite by X-ray analysis. Aluminum chloride pretreatment of elastin inhibits its calcification due to the strong binding of aluminum ions to elastin leading to the alteration in elastin structures
Keywords :
aluminium compounds; biochemistry; cardiology; prosthetics; proteins; 21 d; AlCl3; Ca; X-ray analysis; aluminum chloride pretreatment; aluminum ions binding; bioprosthetic heart valve implants; calcification inhibition; elastin calcification mechanisms; elastin structures alteration; poorly crystallin hydroxyapatite; rat subdermal model; Aluminum; Cardiac disease; Cardiovascular diseases; Hospitals; Implants; Lead compounds; Pediatrics; Proteins; Spectroscopy; Valves;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.803915
