Magnetophoretic Velocity Determined by Space- and Time-Resolved Extinction Profiles

Author

Mykhaylyk, Olga ; Lerche, Dietmar ; Vlaskou, Dialechti ; Schoemig, Veronika ; Detloff, Torsten ; Krause, Daniel ; Wolff, Markus ; Joas, Timo ; Berensmeier, Sonja ; Plank, Christian

Author_Institution

Inst. of Immunology & Exp.Oncology, Tech. Univ. Mnchen, Mnchen, Germany

Volume

6

fYear

2015

fDate

7/7/1905 12:00:00 AM

Firstpage

1

Lastpage

4

Abstract

Magnetophoretic velocity of magnetic nano-objects for biomedical applications was characterized by measuring space- and time-resolved extinction profiles (STEP-Technology) using a customized LUMiReader device equipped with a set of permanent magnets (STEP-MAG). The resulting magnetic fields and gradients in a sample volume enable the operator to choose measurement conditions for magnetic micro- and nanoparticles and their assemblies. The dependence of magnetophoretic velocity on concentration and optical wavelengths indicated assembly of the nano-objects upon magnetophoresis. The method has potential applications in biomedicine to develop advanced materials and protocols for cell separation, tissue engineering, and drug/nucleic acid targeting.

Keywords

biomedical materials; cellular biophysics; magnetic particles; nanomedicine; nanoparticles; permanent magnets; tissue engineering; LUMiReader device; biomedical applications; cell separation; drug acid targeting; magnetic nanoobjects; magnetophoretic velocity; nanoparticles; nucleic acid targeting; optical wavelengths; permanent magnets; space-and time-resolved extinction profiles; tissue engineering; Iron; Magnetic field measurement; Magnetic flux; Magnetic resonance imaging; Magnetic separation; Nanoparticles; Biomagnetic particles; Extinction profiles; Magnetophoretic velocity; Nano-object suspension; Nanomagnetics; extinction profiles; magnetophoretic velocity; nanomagnetics; nanoobject suspension;

fLanguage

English

Journal_Title

Magnetics Letters, IEEE

Publisher

ieee

ISSN

1949-307X

Type

jour

DOI

10.1109/LMAG.2015.2474306

Filename

7229292