Microbubble-mediated intravascular ultrasound imaging and drug delivery

Author

Dixon, Adam J. ; Kilroy, Joseph P. ; Dhanaliwala, Ali H. ; Chen, Johnny L. ; Phillips, Linsey C. ; Ragosta, Michael ; Klibanov, Alexander L. ; Wamhoff, Brian R. ; Hossack, John A.

Author_Institution

Dept. of Biomed. Eng., Univ. of Virginia, Charlottesville, VA, USA

Volume

62

Issue

9

fYear

2015

Firstpage

1674

Lastpage

1685

Abstract

Intravascular ultrasound (IVUS) provides radiation-free, real-time imaging and assessment of atherosclerotic disease in terms of anatomical, functional, and molecular composition. The primary clinical applications of IVUS imaging include assessment of luminal plaque volume and real-time image guidance for stent placement. When paired with microbubble contrast agents, IVUS technology may be extended to provide nonlinear imaging, molecular imaging, and therapeutic delivery modes. In this review, we discuss the development of emerging imaging and therapeutic applications that are enabled by the combination of IVUS imaging technology and microbubble contrast agents.

Keywords

biomedical ultrasonics; diseases; drug delivery systems; image representation; medical image processing; ultrasonic imaging; IVUS imaging technology; anatomical composition; atherosclerotic disease; drug delivery; functional composition; luminal plaque volume assessment; microbubble contrast agents; microbubble-mediated intravascular ultrasound imaging; molecular composition; radiation-free real-time imaging; real-time image guidance; stent placement; therapeutic delivery modes; Atherosclerosis; Catheters; Lesions; Molecular imaging; Transducers; Ultrasonic imaging;

fLanguage

English

Journal_Title

Ultrasonics, Ferroelectrics, and Frequency Control, IEEE Transactions on

Publisher

ieee

ISSN

0885-3010

Type

jour

DOI

10.1109/TUFFC.2015.007143

Filename

7272466