Title :
Microbubble-mediated intravascular ultrasound imaging and drug delivery
Author :
Dixon, Adam J. ; Kilroy, Joseph P. ; Dhanaliwala, Ali H. ; Chen, Johnny L. ; Phillips, Linsey C. ; Ragosta, Michael ; Klibanov, Alexander L. ; Wamhoff, Brian R. ; Hossack, John A.
Author_Institution :
Dept. of Biomed. Eng., Univ. of Virginia, Charlottesville, VA, USA
Abstract :
Intravascular ultrasound (IVUS) provides radiation-free, real-time imaging and assessment of atherosclerotic disease in terms of anatomical, functional, and molecular composition. The primary clinical applications of IVUS imaging include assessment of luminal plaque volume and real-time image guidance for stent placement. When paired with microbubble contrast agents, IVUS technology may be extended to provide nonlinear imaging, molecular imaging, and therapeutic delivery modes. In this review, we discuss the development of emerging imaging and therapeutic applications that are enabled by the combination of IVUS imaging technology and microbubble contrast agents.
Keywords :
biomedical ultrasonics; diseases; drug delivery systems; image representation; medical image processing; ultrasonic imaging; IVUS imaging technology; anatomical composition; atherosclerotic disease; drug delivery; functional composition; luminal plaque volume assessment; microbubble contrast agents; microbubble-mediated intravascular ultrasound imaging; molecular composition; radiation-free real-time imaging; real-time image guidance; stent placement; therapeutic delivery modes; Atherosclerosis; Catheters; Lesions; Molecular imaging; Transducers; Ultrasonic imaging;
Journal_Title :
Ultrasonics, Ferroelectrics, and Frequency Control, IEEE Transactions on
DOI :
10.1109/TUFFC.2015.007143
