• DocumentCode
    3633981
  • Title

    The optimization of oligonucleotide conjugation onto gold nanoparticles for biodetection

  • Author

    R. Buiculescu;M. Comor;N. A. Chaniotakis

  • Author_Institution
    Laboratory of Analytical Chemistry, Department of Chemistry, University of Crete, 71003 Iraklion, Greece
  • Volume
    1
  • fYear
    2009
  • Firstpage
    89
  • Lastpage
    92
  • Abstract
    In this paper we present the optimization procedure for the application of gold nanoparticles as a system for the detection of oligonucleotides. The gold nanoparticles have been conjugated to a pair of 5´-alkanethiol-modified 20 base oligonucleotides, designed to align in a tail-to-head manner. Upon hybridization with the complementary target, the plasmon region of the spectra registers a large red-shift, thus forming a reliable colorimetric system for the detection of oligonucleotides.
  • Keywords
    "Gold","Nanoparticles","Laboratories","Chemistry","Plasmons","Biosensors","Probes","Biological materials","Spectroscopy","Biochemical analysis"
  • Publisher
    ieee
  • Conference_Titel
    Semiconductor Conference, 2009. CAS 2009. International
  • ISSN
    1545-827X
  • Print_ISBN
    978-1-4244-4413-7
  • Electronic_ISBN
    2377-0678
  • Type

    conf

  • DOI
    10.1109/SMICND.2009.5336602
  • Filename
    5336602
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=3633981