Nonhyperemic intracoronary pressure waveform analysis predicts the fractional flow reserve

The fractional flow reserve (FFR) is measured during maximal hyperemia achieved by intracoronary or intravenous vasodilatator. It has been regarded that the nonhyperemic resting pressure ratio (RPR) was not appropriate for exact evaluation of the functional severity of coronary lesion. Some studies suggest, however, that the comparison of the proximal and distal resting waveform of the stenosis may predict the fractional flow reserve (FFR), because the intracoronary waveform has such a high-frequency pressure signal at the closing of aortic valve (notch) that can be decreased by the filter-effect of the stenosis.