Identification of left ventricular systolic dysfunction and contraction inhomogeneity in post-infarction patients using a segmental two-parameter empirical deformable model

Various computational models have been developed with an objective to mimic the left ventricular (LV) wall motion and establishing global and regional parameters for evaluating cardiac performance. Recently, a segmental two-parameter empirical deformable model was introduced which performs a non-rigid registration to derive contraction and rotational parameters describing the LV motion. In this work, we assessed the capability of the segmental model in identifying the impairment of the LV contraction in the post-infarction patients. The correlation between the contraction parameter, α/r_epi defined in this work and the total percentage of infarct was investigated. The temporal pattern of the contraction parameter in each LV segment at the mid ventricular slice was also analyzed throughout the systolic cardiac phases. Our results demonstrated that mean α/r_epi decreased exponentially with an increase in the infarct percentage. While normal subjects showed synchronous contraction for all LV segments, the presence of infarct regions caused LV dyssynchrony, with the infarcted segments demonstrated abnormal contraction patterns.