Semi-supervised color decomposition for histopathological images using exclusive component analysis

In this paper, we propose a color decomposition method for hematoxylin-eosin (H&E) staining images using exclusive component analysis (XCA). We compare against two existing methods: conventional color deconvolution and color decomposition using non-negative matrix factorization method. By comparing the results, it shows that with the minimal effort from the user, the proposed method can not only produce good results, but also extract more information on the structure of cell organelles. Therefore, our proposed color decomposition method can provide more efficient color transformation for the further medical/biomedical image processing, such as segmentation, classification, etc.