Evaluation of accuracy of bolus and burst method for quantitative ultrasound perfusion analysis with various arterial input function models

Quantitative ultrasound perfusion imaging is used to estimate tissue perfusion parameters, such as blood flow, blood volume and mean transit time. The bolus & burst method is one possible approach to quantitative ultrasound perfusion imaging. It has been presented on clinical and preclinical data with two models of the arterial input function. In this study, the two models are compared on simulated and preclinical data to assess the achievable precision and reproducibility.