Title :
Identification of diurnal patterns in insulin action from measured CGM data for patients with T1DM
Author :
Florian Reiterer;Harald Kirchsteiger;Guido Freckmann;Luigi del Re
Author_Institution :
Institute for Design and Control of Mechatronical Systems, Johannes Kepler University Linz, 4040, Austria
fDate :
7/1/2015 12:00:00 AM
Abstract :
We propose a method to identify diurnal changes in insulin action in patients suffering from type 1 diabetes mellitus (T1DM) based on data recorded by continuous glucose monitoring systems (CGMS). In order to do so the data is fitted using a continuous time transfer function including time dependent terms. The identified values for the insulin needs per gram of carbohydrate were compared with the patient-specific carbohydrate-to-insulin-ratios used for the calculation of the bolus insulin needs. A good agreement between the identified parameters and values determined by diabetologists were found. Furthermore, the diurnal variations in insulin action (as inferred from the changes in the patient-specific carbohydrate-to-insulin-ratios) could be reproduced. The identified models, including the diurnal changes in insulin action and the information on the intra-patient variability, have the potential to be used in future studies for managing the blood glucose level of patients, e.g. in a smart bolus calculator.
Keywords :
"Insulin","Sugar","Mathematical model","Diabetes","Data models","Physiology","Measurement uncertainty"
Conference_Titel :
Control Conference (ECC), 2015 European
DOI :
10.1109/ECC.2015.7330516