Identification of cancer-specific motifs in mimotope profiles of serum antibody repertoire

For fighting cancer earlier detection is crucial. The whole proteome can be represented by a random peptide phage display library (RPPDL). This allows to develop an early cancer detection test comparing cancer patients´ and healthy donors´ global peptide profiles of antibody specificities. To decrease the complexity of profiles we developed a method for transforming a list of peptides constituting the mimotope profiles to the list motifs formed by similar peptide sequences. As a result, multiple cancer-specific motifs have been identified.