Development of integrated flexible penetrating microelectrode array with interconnection cable for use in various nervous systems

We developed a flexible and penetrating microelecrode arrays (FPMA) and interconnection cables for neuronal signal recording. For successful implantation of FPMAs into various locations of the nervous system, FPMAs in different dimensions were fabricated using established fabrication process protocols in previous studies. Also, the interconnection cables based on parylene-C were designed and fabricated for implantations in cortex and peripheral nerves. In order to investigate the feasibility of the proposed integrated FPMA with the interconnection cable as a neural recording device, we implanted it onto the cortex of rats and the sciatic nerve of a dog for acute signal recording. Using the developed FPMA integrated with interconnection cable, acute neural signals were successfully recorded from both cortex and sciatic nerves.