Optical observation of DNA translocation dynamics through solid-state nanopores

We report an optical nanopore detection system for investigating DNA translocation dynamics through a nanopore at sub-millisecond and sub-100-nm resolutions. The proposed optical nanopore detection scheme enables the observation of both the translocation process and the escape process. We found different correlation between the translocation time and the escape time, depending on whether the translocation occurs in a folded or unfolded configuration.