Non invasive blood glucose measurement based on Photo-Acoustic Spectroscopy

Diabetes mellitus is a serious disease that affects not only the patient´s internal organs, circulation system and eyesight, but also his entire lifestyle. Determination of blood glucose level is a frequently occurring procedure in diabetes care. As the most common method involves collecting blood drops for chemical analysis, it is invasive and liable to afflict a degree of pain and cause skin injury; therefore, an alternative is needed. This study focuses of designing a non-invasive blood glucose measurement tool using pulsed Photo-Acoustic Spectroscopy. A system has been designed and implemented, as a result it was found that there is a linear mathematical relationship between acoustic signal produced across measuring site and blood glucose concentration. The experimental results were analyzed using Clarke Error Grid Analysis (EGA) with 90% of the results falling into the clinically accurate zone A. the system overall error was (2.6±6.28 mg/dl). This study presents a new effective, simple, portable and safe method that reduces discomfort due to the measurement procedures.