Molecular basis of Huntington´s disease and brain imaging evidence

Huntington´s disease as a neurodegenerative disease is characterized by motor and cognitive impairment. The disease is caused by the mutation of the gene that produces the huntingtin protein causing the repetition of trinucleotide CAG. The mutant protein reacts with other proteins inside and out of the cell causing problems to its normal function and cell death. Recent advances in the signal analysis have engendered EEG with the status of a true brain mapping and brain imaging method able of providing spatio-temporal information regarding brain (dys)function. Authors aim to review objectively and quantitatively the neurophysiological basis of the disease in HD patients as compared to normal controls, with the use of brain imaging in general and EEG brain imaging methods.