DocumentCode :
3749100
Title :
Lower instantaneous entropy of heartbeat dynamics during seizures in untreated temporal lobe epilepsy
Author :
Riccardo Barbieri;Gaetano Valenza;Luca Citi;Fabio Placidi;Francesca Izzi;Maria Albanese;Maria Grazia Marciani;Maria Guerrisi;Andrea Romigi;Nicola Toschi
Author_Institution :
Harvard Medical School, Massachusetts General Hospital, Boston, USA
fYear :
2015
Firstpage :
1037
Lastpage :
1040
Abstract :
Temporal lobe epilepsy (TLE) is associated with dysfunction of the autonomic nervous system. While it is known that heart rate variability (HRV) changes in epilepsy comprise both ictal (CRI) and interictal (INT) autonomic cardiac effects, the mechanisms leading to these alterations are not well understood. In this paper we investigate the alterations in instantaneous autonomic complexity during CRI in untreated TLE using bipolar ECG recordings from 10 patients with at least one seizure originating from temporal regions as recorded by video-EEG monitoring. We isolated artifact-free INT and CRI periods and computed mean values of instantaneous point-process Approximate and Sample Entropy (ipApEn and ipSampEn, respectively). ipApEn was significantly lower (p<;0.02) and ipSampEn was lower (p<;0.065) in CRI vs. INT. The variability (median absolute deviation) of ipApEn was also significantly lower (p<;0.03) in CRI vs INT. Our results suggest that ictal events in untreated TLE are associated with a decrease in heartbeat complexity and its variability, possibly pointing toward subtle autonomic changes which may accompany or precede seizures, and can only be detected using an instantaneous, time resolved approach to quantifying autonomic complexity.
Keywords :
"Heart rate variability","Epilepsy","Complexity theory","Entropy","Temporal lobe","Nonhomogeneous media","Standards"
Publisher :
ieee
Conference_Titel :
Computing in Cardiology Conference (CinC), 2015
ISSN :
2325-8861
Print_ISBN :
978-1-5090-0685-4
Electronic_ISBN :
2325-887X
Type :
conf
DOI :
10.1109/CIC.2015.7411091
Filename :
7411091
Link To Document :
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