Molecular communication and signaling in human cells

Signaling networks in human cells convey signals from the cell membrane to specific target molecules via biochemical interactions, to control a variety of cellular functions. We have modeled signaling networks as communication channels where molecules communicate with each other to transfer signals. We have defined and computed the fundamental parameters of transmission error probability and signaling capacity in signaling networks. This systematic approach can be used to understand how cell signaling errors and malfunctioning molecules may contribute to the development of complex human disorders with unknown molecular bases.