Quantitative performance of iterative algorithms, with and without PSF and TOF, in the conditions of a dynamic cardiac 13N-ammonia study

Iterative reconstruction algorithm are the standard reconstruction for clinical imaging. For quantification purposes in kinetic modelling sometimes analytical reconstruction are preferred for their linearity and the absence of bias at the low statistics typical of dynamic studies. Time-Of-Flight (TOF) technology was suggested to be able to improve the efficacy of random coincidences correction, to reduce noise and should be able to reduce bias. Point Spread Function modelling (PSF) can also improve quantification accuracy recovery resolution degrading effects.