Diffusion of particles adhering to liposomes

In the past decade, nanoparticles have been reported to show cellular toxicity. However, biophysical mechanism of the toxicity, such as uptake process of nanoparticles into a cell, is still unclear. In this study, we used an artificial cell, such as cell-seized liposomes, to clarify the physical mechanism of the interaction between nano/submicro particles and lipid bilayer membranes. First, we focused on the membrane deformation induced by particle adsorption. Then, we measured the lateral diffusion of particles on the membrane surface.