Title :
Detection of base pair charges during DNA extension with Si nanowire FETs towards DNA sequencing
Author :
Yuchen Liang;Silu Zhang;Walter Hu
Author_Institution :
Dept. of Electrical Engineering, University of Texas at Dallas, Richardson, TX 75080, USA
Abstract :
Designed DNA templates were anchored onto the surface of Si nanowire (SiNW) FETs. Then base pair (BP) extension reactions were performed on the DNA templates. The charges of newly formed BPs induced shifts of device Id-Vg curves. Vg shifts linearly with the number of BPs with a strong signal of ?10 mV/BP, indicating a great potential for DNA sequencing by detecting intrinsic charges of DNA backbones.
Conference_Titel :
Nanotechnology Materials and Devices Conference (NMDC), 2015 IEEE
DOI :
10.1109/NMDC.2015.7439279
