Title :
Modeling effects of nitric oxide on oxygen consumption in the microcirculation
Author :
Lamkin-Kennard, Kathleen ; Buerk, Donald G. ; Barbee, Kenneth ; Wootton, David ; Jaron, Dov
Author_Institution :
Dept. of Mech. Eng., Drexel Univ., Philadelphia, PA, USA
Abstract :
Nitric oxide (NO) is a powerful vasodilator that regulates blood flow and inhibits mitochondrial oxygen (O2) consumption. We present a mathematical model to show the effects NO has on the regulation of oxygen consumption in the microcirculation. We use expressions based on experimental data to simulate the steady state coupled mass transport of O2 and NO through blood vessels, the vascular wall, and tissue. Our preliminary modeling studies, using a cylindrical geometry, show that the inhibition of O2 consumption by NO increases tissue PO2 farther from the vessel, The effect is more pronounced at lower PO2 values
Keywords :
biodiffusion; blood; blood vessels; haemodynamics; nitrogen compounds; physiological models; NO; arterioles; biotransport; blood flow; blood vessels; capillaries; concentration profiles; cylindrical geometry; layered structure; mathematical model; microcirculation; modified Michaelis-Menten kinetics; nitric oxide vasodilator effects; one-dimensional radial diffusion equation; oxygen consumption regulation; pseudo-first-order rate constant; reversible inhibitor; scavenging; steady state coupled mass transport; tissue; vascular endothelium; vascular wall; Blood flow; Equations; Geometry; Mathematical model; Oxygen; Plasma simulation; Plasma sources; Power engineering and energy; Solid modeling; Steady-state;
Conference_Titel :
Bioengineering Conference, 2002. Proceedings of the IEEE 28th Annual Northeast
Conference_Location :
Philadelphia, PA
Print_ISBN :
0-7803-7419-3
DOI :
10.1109/NEBC.2002.999450
