Title :
Small-field angiographic imaging of tumor blood vessels using synchrotron radiation
Author :
Umetani, K. ; Yamashita, T. ; Maehara, N. ; Imai, S. ; Kajihara, Y.
Author_Institution :
Life & Environ. Div., Japan Synchrotron Radiat. Res. Inst., Hyogo, Japan
Abstract :
Microangiography with about 10 μm resolution has been carried out for depicting angiogenic vessels in a rabbit model of cancer using a high-resolution detector and a third generation synchrotron radiation source at SPring-8. In synchrotron radiation radiography, a long source-to-object distance and a small source spot can produce high-resolution images. VX2 carcinoma had been transplanted in a rabbit auricle. By using this imaging system, small tumor blood vessels with diameters of 20-30 μm in an immature vascular network produced by angiogenesis were visualized after contrast material injection to the auricular artery.
Keywords :
blood vessels; cancer; diagnostic radiography; image resolution; synchrotron radiation; tumours; 20 to 30 micron; SPring-8; VX2 carcinoma; angiogenesis; angiogenic vessels; auricular artery; cancer; contrast material injection; high-resolution detector; immature vascular network; long source-to-object distance; microangiography; rabbit auricle; rabbit model; resolution; small source spot; small-field angiographic imaging; synchrotron radiation; synchrotron radiation radiography; third generation synchrotron radiation source; tumor blood vessels; Biomedical imaging; Blood vessels; Cancer detection; Diagnostic radiography; High-resolution imaging; Neoplasms; Rabbits; Radiation detectors; Synchrotron radiation; Visualization;
Conference_Titel :
Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE
Print_ISBN :
0-7803-7211-5
DOI :
10.1109/IEMBS.2001.1017254
