Signal and noise in gene length distributions of decoded genomes

Author

Tözeren, Aydin ; Weston, Neil D. ; Ou, Zihang

Author_Institution

Dept. of Biomed. Eng., Catholic Univ. of America, Washington, DC, USA

Volume

3

fYear

2001

fDate

2001

Firstpage

2914

Abstract

Development of objective measures for comparing genome data has become an important goal in computational genomics. Gene length distribution histograms derived from the predicted protein-coding gene populations of decoded genomes were considered as tools for genomic comparison. The first and second moments of the histograms map the decoded genomes as isolated points onto an Euclidean plane. The clustering of the genomic points on the plane preserves the separation of the three domains of life. The mapping of genomes onto a plane allows for the use of vector analysis in the study of genome evolution.

Keywords

biology computing; evolution (biological); genetics; noise; proteins; vectors; Euclidean plane; computational genomics; decoded genomes; first moments; gene length distribution histograms; genome evolution; genomic points clustering; isolated points; life domains separation; predicted protein-coding gene populations; second moments; vector analysis; Archaea; Bioinformatics; Biomedical engineering; Decoding; Genomics; Histograms; Microorganisms; Organisms; Proteins; Signal analysis;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE

ISSN

1094-687X

Print_ISBN

0-7803-7211-5

Type

conf

DOI

10.1109/IEMBS.2001.1017400

Filename

1017400