Liposomal delivery vehicles of paclitaxel

Author

Sa, Li ; YongGang, Zhao ; Zhiqi, Zhang ; Yuhong, Xu

Author_Institution

Dept. of Bio-medical Eng., Shanghai Jiao Tong Univ., China

Volume

3

fYear

2001

fDate

2001

Firstpage

2931

Abstract

Paclitaxel stabilizes microtubules while inhibits mitotic spindle formation. It has been found to be effective in treating several solid cancers. The aim of this study was to incooperate paclitaxel in conventional and PEGylated liposomes, and to evaluate the antiproliferative effects of different formulations on MCF-7 and ZR75-1 cell lines. MTT assay was used to determine the growth inhibition of the cell line by paclitaxel. A significant dose-dependent inhibition of proliferation was found after the cells were exposured to certain liposomal paclitaxel preparations, suggesting the possible use of liposomes as effective palitaxel delivery devices.

Keywords

biochemistry; cancer; cellular transport; drug delivery systems; MCF-7 cell lines; ZR75-1 cell lines; anticancer agent; breast cancer; breast carcinoma cells; dose-dependent inhibition; epithelial sheet-like morphology; human tumors; liposomal delivery vehicles; microtubules stabilization; monolayers; paclitaxel; proliferation inhibition; solid tumor masses; Automotive engineering; Biotechnology; Breast cancer; Breast neoplasms; Cells (biology); Drugs; Educational institutions; Solids; Tumors; Vehicles;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE

ISSN

1094-687X

Print_ISBN

0-7803-7211-5

Type

conf

DOI

10.1109/IEMBS.2001.1017405

Filename

1017405