Title :
Liposomal delivery vehicles of paclitaxel
Author :
Sa, Li ; YongGang, Zhao ; Zhiqi, Zhang ; Yuhong, Xu
Author_Institution :
Dept. of Bio-medical Eng., Shanghai Jiao Tong Univ., China
Abstract :
Paclitaxel stabilizes microtubules while inhibits mitotic spindle formation. It has been found to be effective in treating several solid cancers. The aim of this study was to incooperate paclitaxel in conventional and PEGylated liposomes, and to evaluate the antiproliferative effects of different formulations on MCF-7 and ZR75-1 cell lines. MTT assay was used to determine the growth inhibition of the cell line by paclitaxel. A significant dose-dependent inhibition of proliferation was found after the cells were exposured to certain liposomal paclitaxel preparations, suggesting the possible use of liposomes as effective palitaxel delivery devices.
Keywords :
biochemistry; cancer; cellular transport; drug delivery systems; MCF-7 cell lines; ZR75-1 cell lines; anticancer agent; breast cancer; breast carcinoma cells; dose-dependent inhibition; epithelial sheet-like morphology; human tumors; liposomal delivery vehicles; microtubules stabilization; monolayers; paclitaxel; proliferation inhibition; solid tumor masses; Automotive engineering; Biotechnology; Breast cancer; Breast neoplasms; Cells (biology); Drugs; Educational institutions; Solids; Tumors; Vehicles;
Conference_Titel :
Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE
Print_ISBN :
0-7803-7211-5
DOI :
10.1109/IEMBS.2001.1017405
