Title :
Mathematical model and experimental design for human IgG diffusion
Author :
Giacomini, M. ; Bertone, S. ; Peragallo, I. ; Ruggiero, C.
Author_Institution :
Dip. of Informatics Syst. & Telematics, Univ. of Genova, Italy
Abstract :
A model of human IgG diffusion is presented. With the aid of computer based simulation, it will help members of the consortium of the EU funded project "Tissue engineered nerve repair devices: development of European medical implantable devices and research training focus" to predict the incorporation/release diffusion dynamics of soluted, including therapeutic antibody, in engineered tissues. The experimental design which will be used to identify the model parameters is also presented with the first experimental results.
Keywords :
biodiffusion; biological tissues; design of experiments; digital simulation; neurophysiology; patient treatment; physiological models; prosthetics; European medical implantable devices; computer based simulation; engineered tissues; engineering bioartificial nerve grafts; experimental design; human IgG diffusion; incorporation diffusion dynamics; mathematical model; model parameters; release diffusion dynamics; research training focus; soluted antibody; surgical peripheral nerve repair; therapeutic antibody; tissue engineered nerve repair devices; Biological materials; Biomedical engineering; Design for experiments; Drugs; Fluorescence; Humans; Informatics; Mathematical model; Medical treatment; Polymers;
Conference_Titel :
Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE
Print_ISBN :
0-7803-7211-5
DOI :
10.1109/IEMBS.2001.1017421
