Title :
Cellular sensing devices for assessing chemicals
Author :
Aizawa, M. ; Kamei, K. ; Haruyama, T. ; Kobatake, E.
Author_Institution :
Graduate Sch. of Bioscience & Biotechnol., Tokyo Inst. of Technol., Yokohama, Japan
Abstract :
Several types of cellular biosensors have been developed for assessing chemicals, in which the cell responses to chemicals are transduced to the sensor outputs in various manners. The cell layer is fixed in the vicinity of the signal transducer. As an example, assessment of immunomodulating chemicals has been performed with a cellular biosensor based on electrochemical determination of the inducible nitrogen oxide synthase (iNOS) expression in a macrophage-like cell.
Keywords :
biochemistry; biomembrane transport; biosensors; cellular biophysics; chemioception; NO; animal test alternatives; biological effects of chemicals; cell layer; cell responses; cellular biosensors; cellular sensing devices; chemical assessment; electrochemical determination; immunomodulating chemicals; inducible nitrogen oxide synthase expression; intracellular information networks; macrophage-like cell; primary screening test; sensor outputs; signal transducer; Animals; Biosensors; Cells (biology); Cellular networks; Chemical and biological sensors; Chemical sensors; Chemical technology; Electrodes; Nitrogen; Testing;
Conference_Titel :
Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE
Print_ISBN :
0-7803-7211-5
DOI :
10.1109/IEMBS.2001.1017432
