Cell-specific ionic models of cardiac pacemaker activity

Author

Dokos, S. ; Cloherty, S.L. ; Lovell, N.H. ; Zaza, A.

Author_Institution

Graduate Sch. of Biomed. Eng., New South Wales Univ., Sydney, NSW, Australia

Volume

1

fYear

2001

fDate

2001

Firstpage

17

Abstract

We have developed a generic ionic model of single-cell rabbit sinoatrial node (SAN) electrical activity, employing Markov-state kinetics for membrane ionic currents. By suitable choice of parameters, the model is able to accurately reproduce a wide range of action potential waveforms recorded from individual SAN cells in the laboratory. Advantages of this approach include the ability to quantitatively investigate the contribution of ion currents underlying pacemaker and action potential activity from any given SAN myocyte recording.

Keywords

bioelectric potentials; biomembrane transport; cardiology; neurophysiology; physiological models; Markov-state kinetics; action potential activity; action potential waveforms reproduction; cardiac electrophysiology; generic ionic model; mathematical model; membrane ionic currents; single-cell rabbit sinoatrial node electrical activity; Biomedical engineering; Biomembranes; Biotechnology; Cells (biology); Kinetic theory; Laboratories; Mathematical model; Pacemakers; Rabbits; Storage area networks;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE

ISSN

1094-687X

Print_ISBN

0-7803-7211-5

Type

conf

DOI

10.1109/IEMBS.2001.1018832

Filename

1018832