Investigation of blood proteins adsorption on coated and uncoated hollow fiber surfaces in extracorporeal circuits during cardiopulmonary bypass

Author

Kocakulak, M. ; Gunaydin, S. ; Saber, R. ; Kocum, Cengiz ; Farsak, B. ; Bingol, N. ; Sari, T. ; Yorgancioglu, C. ; Zorlutuna, Y. ; Ayhan, Hayriye ; Piskin, E.

Author_Institution

Chem. Eng. Dept., Hacettepe Univ., Ankara, Turkey

Volume

1

fYear

2001

fDate

2001

Firstpage

459

Abstract

Poly(2-methoxyethylacrylate)-PMEA theoretically reduces protein and platelet adsorption. 55 patients undergoing three-vessel coronary artery bypass were operated with PMEA coated and uncoated extracorporeal circuits. Contrary to coated circuits, it is observed that more protein adhesion occurs on uncoated fiber surfaces. As a clinical observation, less bleeding was observed for coated system.

Keywords

adhesion; adsorption; blood; cardiovascular system; coagulation; proteins; surgery; Xcoating model oxygenator; aggregation; amphiphilic organic polymer; blood proteins adsorption; cardiopulmonary bypass; coated hollow fiber surfaces; extracorporeal circuits; poly(2-methoxyethylacrylate) coating; postoperative hemorrhage; protein adhesion; protein desorption; three-vessel coronary artery bypass; uncoated hollow fiber surfaces; Adhesives; Arteries; Biomedical engineering; Blood; Cardiology; Chemical engineering; Circuits; Polymer films; Proteins; Surgery;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE

ISSN

1094-687X

Print_ISBN

0-7803-7211-5

Type

conf

DOI

10.1109/IEMBS.2001.1018963

Filename

1018963