Solute dynamics of patient artificial kidney system and assessment adequacy of hemodialysis

Summary form only given. A variable volume compartment model and a fixed volume model of solute dynamics were proposed to study the adequacy of hemodialysis. Based on the BUN concentration in dialysate of seven patients during hemodialysis. The parameters in these models were defined. Using these models, the changing of BUN concentration in blood during hemodialysis can be estimated and BUN concentration in blood sometime after hemodialysis can also be predicted. The results of computer simulation show that after hemodialysis, the rebound truly existed. One reason of rebound may be disequilibrium distribution of urea in extracellular fluid and intracellular fluid. Another reason may be the continuous production of urea. We propose a new assessing index independent of experience of doctors or KT/V to determine the adequacy of hemodialysis in a clinic. We hope this index can help doctors draft an adequate program for hemodialysis.