MEMS-based systems for DNA sequencing and forensics

Author

Ehrlich, Daniel ; Carey, Loucinda ; Chiou, Jeffrey ; Desmarais, Samantha ; El-Difrawy, Sameh ; Koutny, Lance ; Lam, Roger ; Matsudaira, Paul ; Mckenna, Brian ; Mitnik-Gankin, Luba ; Neil, Tom O. ; Novotny, Mark ; Srivastava, Alok ; Streechon, Phil ; Timp,

Author_Institution

Whitehead Inst. for Biomed. Res., MIT, Cambridge, MA, USA

Volume

1

fYear

2002

fDate

2002

Firstpage

448

Abstract

We outline some of the most important scientific problems that were overcome in this multiyear project. These include (a) the high-yield microfabrication of zero-defect bonded glass plates at sizes greatly exceeding semiconductor fabrication, (b) the integration of electrodes, reservoirs, and high-pressure seals into these plates, (c) detector optimization for the required very high rate data acquisition and (d) microfluidics issues and optimizations related to channel geometry.

Keywords

DNA; biological techniques; microelectrodes; microfluidics; molecular biophysics; DNA sequencing; MEMS-based systems; channel geometry; detector optimization; electrodes integration; forensics; high-pressure seals; high-yield microfabrication; microfluidics issues; most important scientific problems; multiyear project; reservoirs; semiconductor fabrication; very high rate data acquisition; zero-defect bonded glass plates; Bonding; DNA; Data acquisition; Detectors; Electrodes; Fabrication; Forensics; Glass; Reservoirs; Seals;

fLanguage

English

Publisher

ieee

Conference_Titel

Sensors, 2002. Proceedings of IEEE

Print_ISBN

0-7803-7454-1

Type

conf

DOI

10.1109/ICSENS.2002.1037134

Filename

1037134