Title :
A novel fluidic network system for enzyme batch-immobilization and blood sensing
Author :
Tseng, Fan-Gang ; Lin, Kuang-Hua ; Chieng, Ching-Chang
Author_Institution :
ESS Dept., Nat. Tsing Hua Univ., Hsinchu, Taiwan
Abstract :
This paper reports a novel fluidic network system for immobilizing various enzymes on arrays in parallel for blood sensing. The network was fabricated by polymer-MEMS technology with plasma treatment on channel surface, and the liquids were driven by surface tension passively without external active power source. Enzyme based glucose sensing was employed as a model system in this fluidic network, and the testing result showed precise enzyme immobilization and functional sensor response. The fully fabricated glucose sensor in this fluidic network system demonstrated a sensitivity of 5.42 nA/mM, and a response linearly related to the glucose concentration. This novel fluidic network can be applied to blood sensing for clinical or domestic usage.
Keywords :
biosensors; blood; microfluidics; organic compounds; proteins; surface tension; blood sensing; clinical usage; domestic usage; enzyme batch-immobilization; external active power source; fluidic network system; functional sensor response; glucose concentration; linearly related response; plasma treatment; polymer-MEMS technology; precise enzyme immobilization; surface tension; Biochemistry; Blood; Liquids; Plasma sources; Polymers; Power system modeling; Sensor systems; Sugar; Surface tension; Surface treatment;
Conference_Titel :
Sensors, 2002. Proceedings of IEEE
Print_ISBN :
0-7803-7454-1
DOI :
10.1109/ICSENS.2002.1037186
