Title :
Design considerations for on-chip THz analysis of biomolecules
Author :
Baras, T. ; Kleine-Ostmann, T. ; Koch, M.
Author_Institution :
Inst. fur Hochfrequenztech., Technische Univ. Braunschweig, Germany
Abstract :
Recently the marker free distinction between different kinds of biomolecules, e.g. hybridised (double-stranded) DNA (HDNA) and denatured (single-stranded) DNA (DDNA) using THz time-domain on-chip analysis has been demonstrated. Here we numerically examine the influence of critical experimental parameters on the transmission characteristics of a variety of microstrip resonators loaded with test samples of different thickness and refractive index.
Keywords :
DNA; biological techniques; biosensors; electric sensing devices; microstrip resonators; time-domain analysis; DDNA; HDNA; critical parameters; denatured DNA; design considerations; double-stranded DNA; hybridised DNA; marker free distinction; microstrip resonators; on-chip THz biomolecule analysis; refractive index; single-stranded DNA; test sample thickness; time-domain on-chip analysis; transmission characteristics; DNA; Fluorescence; Genetics; Microstrip resonators; Molecular biophysics; Refractive index; Resonance; Sequences; Switches; Testing;
Conference_Titel :
Terahertz Electronics Proceedings, 2002. IEEE Tenth International Conference on
Print_ISBN :
0-7803-7630-7
DOI :
10.1109/THZ.2002.1037594
