Design considerations for on-chip THz analysis of biomolecules

Author

Baras, T. ; Kleine-Ostmann, T. ; Koch, M.

Author_Institution

Inst. fur Hochfrequenztech., Technische Univ. Braunschweig, Germany

fYear

2002

fDate

2002

Firstpage

77

Lastpage

80

Abstract

Recently the marker free distinction between different kinds of biomolecules, e.g. hybridised (double-stranded) DNA (HDNA) and denatured (single-stranded) DNA (DDNA) using THz time-domain on-chip analysis has been demonstrated. Here we numerically examine the influence of critical experimental parameters on the transmission characteristics of a variety of microstrip resonators loaded with test samples of different thickness and refractive index.

Keywords

DNA; biological techniques; biosensors; electric sensing devices; microstrip resonators; time-domain analysis; DDNA; HDNA; critical parameters; denatured DNA; design considerations; double-stranded DNA; hybridised DNA; marker free distinction; microstrip resonators; on-chip THz biomolecule analysis; refractive index; single-stranded DNA; test sample thickness; time-domain on-chip analysis; transmission characteristics; DNA; Fluorescence; Genetics; Microstrip resonators; Molecular biophysics; Refractive index; Resonance; Sequences; Switches; Testing;

fLanguage

English

Publisher

ieee

Conference_Titel

Terahertz Electronics Proceedings, 2002. IEEE Tenth International Conference on

Print_ISBN

0-7803-7630-7

Type

conf

DOI

10.1109/THZ.2002.1037594

Filename

1037594