Title :
Diagnostic imaging of breast cancer microvasculature with optoacoustic tomography
Author :
Oraevsky, A.A. ; Savateeva, E.V. ; Solomatin, S.V. ; Karabutov, A.A. ; Gatalica, Z. ; Khamapirad, T.
Author_Institution :
Center for Biomed. Eng., Univ. of Texas Med. Branch, Galveston, TX, USA
Abstract :
We report first clinical results of diagnostic imaging of breast cancer patients with optoacoustic tomography (OAT). OAT combines the most compelling features of light and sound for medical imaging: high tissue contrast and excellent resolution. Aggressive malignant tumors were diagnosed based on relative concentration of oxy- and deoxy-hemoglobin in the tumor microvasculature. Optoacoustic images of breast cancer were acquired at two laser wavelengths matching maximum of oxyhemoglobin (1064-nm) and deoxyhemoglobin (760-nm). Quantitative analysis of two-color optoacoustic images was correlated with immunohistology of biopsy specimens. The possibility for noninvasive differentiation of malignant carcinoma from benign fibroadenoma was demonstrated.
Keywords :
biomedical optical imaging; biomedical ultrasonics; blood vessels; cancer; laser applications in medicine; mammography; optical tomography; photoacoustic effect; 1064 nm; 760 nm; benign fibroadenoma; biopsy specimens; deoxyhemoglobin; first clinical results; immunohistology; malignant carcinoma; medical diagnostic imaging; noninvasive differentiation; oxyhemoglobin; two-color optoacoustic images; Biomedical imaging; Biopsy; Breast cancer; Breast neoplasms; High-resolution imaging; Image analysis; Image resolution; Immune system; Malignant tumors; Tomography;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1053306
