Diagnostic imaging of breast cancer microvasculature with optoacoustic tomography

Author

Oraevsky, A.A. ; Savateeva, E.V. ; Solomatin, S.V. ; Karabutov, A.A. ; Gatalica, Z. ; Khamapirad, T.

Author_Institution

Center for Biomed. Eng., Univ. of Texas Med. Branch, Galveston, TX, USA

Volume

3

fYear

2002

fDate

23-26 Oct. 2002

Firstpage

2329

Abstract

We report first clinical results of diagnostic imaging of breast cancer patients with optoacoustic tomography (OAT). OAT combines the most compelling features of light and sound for medical imaging: high tissue contrast and excellent resolution. Aggressive malignant tumors were diagnosed based on relative concentration of oxy- and deoxy-hemoglobin in the tumor microvasculature. Optoacoustic images of breast cancer were acquired at two laser wavelengths matching maximum of oxyhemoglobin (1064-nm) and deoxyhemoglobin (760-nm). Quantitative analysis of two-color optoacoustic images was correlated with immunohistology of biopsy specimens. The possibility for noninvasive differentiation of malignant carcinoma from benign fibroadenoma was demonstrated.

Keywords

biomedical optical imaging; biomedical ultrasonics; blood vessels; cancer; laser applications in medicine; mammography; optical tomography; photoacoustic effect; 1064 nm; 760 nm; benign fibroadenoma; biopsy specimens; deoxyhemoglobin; first clinical results; immunohistology; malignant carcinoma; medical diagnostic imaging; noninvasive differentiation; oxyhemoglobin; two-color optoacoustic images; Biomedical imaging; Biopsy; Breast cancer; Breast neoplasms; High-resolution imaging; Image analysis; Image resolution; Immune system; Malignant tumors; Tomography;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1053306

Filename

1053306