Sensitivity of a hand-held indentation Probe for measuring the stiffness of articular cartilage

The in vivo assessment of the quality of cartilage is a critical tool to determine how to clinically treat damaged cartilage. Utilizing non-destructive indentation, a hand-held instrument (ACTAEON™ Probe) can be used to rapidly measure the stiffness of articular cartilage, which can then be correlated to cartilage condition. The engineering design aspects of the instrument and the feasibility testing which have been undertaken using both animal and human knee joints are presented. An integrated series of tests were performed to determine whether the Probe is sensitive enough to detect early degenerative changes in articular cartilage and to examine if it is dependent on the thickness of the cartilage being tested. Results demonstrated that there is no effect of thickness on the Probe measurements, that the Probe is sensitive enough to detect different levels of cartilage degeneration, and that Probe data correlate well with traditional creep indentation testing. This study demonstrates the utility of the Probe for detecting degenerative changes in animal and human joints.