Towards image-guided gene therapy delivery

Author

Harris, S.S. ; Gebhart, S.C. ; Donnelly, E. ; Galloway, RL

Author_Institution

Dept. of Biomed. Eng., Vanderbilt Univ., Nashville, TN, USA

Volume

2

fYear

2002

fDate

2002

Firstpage

1192

Abstract

Image-guided procedures have grown steadily over the past decade. In most the aim is the resection or destruction of diseased tissue. Gene therapy agents have a very limited diffusion distance which limits their usefulness. A technique for guiding the delivery of gene therapy using image-guidance is under development. When complete, it would allow the delivery of diffusion limited therapies to a broad volume. We present the results of the delivery system development and the accuracy testing.

Keywords

biodiffusion; biological tissues; computerised tomography; diseases; genetics; image registration; medical image processing; patient treatment; CT registration; accuracy testing; apple-box combination; delivery system development; diseased tissue destruction; diseased tissue resection; image-guided gene therapy delivery; infrared light emitting diodes; limited diffusion distance; optically tracked devices; root-mean-square fiducial localization error; Biomedical engineering; Biomedical imaging; Gene therapy; Medical treatment; Needles; Optical devices; Probes; Radiology; Surgery; Testing;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1106343

Filename

1106343