Three-dimensional model of cardiac electromechanics: cell to organ

Author

Usyk, Taras P. ; Belik, Mary Ellen ; Michailova, Anushka ; McCulloch, Andrew D.

Author_Institution

Dept. of Bioeng., California Univ., San Diego, La Jolla, CA, USA

Volume

2

fYear

2002

fDate

2002

Firstpage

1220

Abstract

We describe a new computational model that integrates the cellular biophysics of ventricular myocytes into structurally detailed three-dimensional models of the ventricular walls during the whole cardiac cycle. The new model is suitable for investigating hypotheses regarding excitation-contraction coupling in the intact heart.

Keywords

bioelectric phenomena; biomechanics; cardiology; cellular biophysics; finite element analysis; physiological models; cardiac electromechanics; complex interactions; congestive heart failure; coronary heart disease; crossbridge kinetics; electrical behavior; excitation-contraction coupling; heart diseases; intracellular calcium cycling; mechanical behavior; mechanoelectric feedback; transmembrane ionic currents; ventricular arrhythmias; ventricular myocytes; ventricular walls; Biomedical engineering; Calcium; Cellular biophysics; Computational modeling; Couplings; Finite element methods; Heart; Hemodynamics; Kinetic theory; Solid modeling;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1106357

Filename

1106357