Progression of left ventricular wall thickness during pressure-overload left ventricular hypertrophy

Pressure-overload in terms of decreased arterial compliance (C) and increased vascular resistance (Rs) was used in conjunction with a negative feedback control model to predict left ventricular (LV) wall thickness growth over a prescribed time period. The progression of left ventricular wall thickness growth was found to change proportionally with the peak systolic pressure and the extent of the combination of a reduction in C and an increase in Rs.