Remodeling and elasticity changes in human vein grafts

Author

Jacot, J.G. ; Abduah, I. ; Belkin, M. ; Donaldson, M.C. ; Whittemore, A.D. ; Conte, M.S.

Author_Institution

Dept. of Biomed. Eng., Boston Univ., MA, USA

Volume

2

fYear

2002

fDate

2002

Firstpage

1325

Abstract

Duplex ultrasound measurements of patients (N=65) undergoing lower extremity bypass with autologous veins were taken at surgery and multiple times after surgery. Changes in lumen diameter were correlated with changes in external graft diameter (p<0.001) but not with wall area. Changes in lumen diameter were also negatively correlated with initial lumen diameter (p<0.05). Grafts showed a marked increase in wall elastic modulus between 1 and 3 months postoperatively. In this same time, graft wall tension decreased to a level not significantly different to that in the normal superficial femoral artery (SFA). These results suggest complex remodeling of vein grafts with wall growth that alleviates wall tension, independent from changes in lumenal diameter.

Keywords

biomechanics; biomedical ultrasonics; blood vessels; elasticity; surgery; autologous veins; complex remodeling; duplex ultrasound measurements; elasticity changes; external graft diameter; graft wall tension; human vein grafts; initial lumen diameter; lower extremity bypass; lumen diameter; multiple times; normal superficial femoral artery; patients; surgery; vein bypass grafting; wall area; wall elastic modulus; wall growth; Elasticity; Extremities; Humans; Image segmentation; Pulse measurements; Surgery; Thickness measurement; Ultrasonic imaging; Ultrasonic variables measurement; Veins;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1106410

Filename

1106410