Title :
Dynamical instability of cardiac action potentials: cause and effect
Author :
Otani, Niels F. ; Li, Mingyi
Author_Institution :
Dept. of Biomed. Eng., Case Western Reserve Univ., Cleveland, OH, USA
Abstract :
An eigenmode method is used to develop insight into the mechanism behind alternans, memory, and conserved and nearly-conserved quantities in small cardiac preparations undergoing constant pacing. The time course of the right eigenmodes of perturbations about the steady state determine the process by which alternans and memory are produced. The left eigenvalues define the conservation and near-conservation laws. Matrix "cleaning" techniques further clarify the stability of action potentials during constant pacing.
Keywords :
bioelectric potentials; eigenvalues and eigenfunctions; electrocardiography; matrix algebra; medical signal processing; physiological models; stability; alternans; cardiac action potentials; cardiac electrophysiology; conservation laws; constant pacing; dynamical instability; eigenmode analysis; eigenvalues; electrophysiology; matrix cleaning techniques; memory; near-conservation laws; perturbations; small cardiac preparations; Acceleration; Biomedical engineering; Biomembranes; Eigenvalues and eigenfunctions; Mathematical programming; Morphology; Multidimensional systems; Stability; Steady-state;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1106427
