DocumentCode
385508
Title
The unifying role of cytoskeletal prestress in micromechanics of the adherent cell
Author
Stamenovic, D. ; Tolic-Norrelykke, I.M. ; Fredberg, J.J. ; Wang, N.
Author_Institution
Dept. of Biomed. Eng., Boston Univ., MA, USA
Volume
2
fYear
2002
fDate
2002
Firstpage
1466
Abstract
We measured cytoskeletal prestress and stiffness in cultured airway smooth muscle cells treated with graded doses of histamine and isoproterenol, and with colchicine. The stiffness increased in proportion with increasing prestress. This feature is the hallmark of systems known as stress-supported structures. In addition, microtubules balanced a substantial, but relatively small fraction of the prestress.
Keywords
adhesion; biomechanics; cellular biophysics; elasticity; lung; muscle; cell shape alterations; cellular biomechanics; coichicine; cultured airway smooth muscle cells; cytoskeletal prestress; histamine; isoproterenol; microtubules; stress-supported structures; Biomedical engineering; Biomedical measurements; Biomembranes; Cells (biology); Medical treatment; Muscles; Public healthcare; Resists; Shape; Tensile stress;
fLanguage
English
Publisher
ieee
Conference_Titel
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
ISSN
1094-687X
Print_ISBN
0-7803-7612-9
Type
conf
DOI
10.1109/IEMBS.2002.1106486
Filename
1106486
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