Title :
The effects of epithelial surface topography on cell stresses during airway reopening
Author :
Jacob, A.M. ; Gaver, D.P.
Author_Institution :
Dept. of Biomed. Eng., Tulane Univ., New Orleans, LA, USA
Abstract :
A collapsed pulmonary system is one whose airways are blocked by a thin liquid film that obstructs airflow. A bubble of air must peel apart these airways´ walls in order to reopen them. This introduces large stresses on the pulmonary epithelial cells of a magnitude that could alter their biological functioning. We present a computational model whose goal it is to locally quantify the stresses acting on these cells.
Keywords :
biomechanics; bubbles; cellular biophysics; liquid films; lung; physiological models; pneumodynamics; air bubble; airflow; airway reopening; airway walls; airways; biological functioning; cell stresses; collapsed pulmonary system; computational model; epithelial surface topography; large stresses; lung; pulmonary epithelial cells; thin liquid film; Biological system modeling; Biology computing; Biomedical engineering; Cells (biology); Computational modeling; Jacobian matrices; Stress; Surface tension; Surface topography; Ventilation;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1106496
