The effects of epithelial surface topography on cell stresses during airway reopening

Author

Jacob, A.M. ; Gaver, D.P.

Author_Institution

Dept. of Biomed. Eng., Tulane Univ., New Orleans, LA, USA

Volume

2

fYear

2002

fDate

2002

Firstpage

1483

Abstract

A collapsed pulmonary system is one whose airways are blocked by a thin liquid film that obstructs airflow. A bubble of air must peel apart these airways´ walls in order to reopen them. This introduces large stresses on the pulmonary epithelial cells of a magnitude that could alter their biological functioning. We present a computational model whose goal it is to locally quantify the stresses acting on these cells.

Keywords

biomechanics; bubbles; cellular biophysics; liquid films; lung; physiological models; pneumodynamics; air bubble; airflow; airway reopening; airway walls; airways; biological functioning; cell stresses; collapsed pulmonary system; computational model; epithelial surface topography; large stresses; lung; pulmonary epithelial cells; thin liquid film; Biological system modeling; Biology computing; Biomedical engineering; Cells (biology); Computational modeling; Jacobian matrices; Stress; Surface tension; Surface topography; Ventilation;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1106496

Filename

1106496